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Re: [IP] Eli Lily comments

On Thu, 8 Jan 1998 email @ redacted wrote:

> Yes, I noticed looking on the Eli Lily Website and having no data
> for the Regular + Humalog mixtures.  What exactly is Velosulin? is that
> the same as regular?  honestly, I have never heard of it other than on

More or less. It is Novo-Nordisks insulin buffered specifically for use 
in pumps. Its full name is Velosulin BR and it is carried by most 
pharmacys or they can get it for you.  Probably basically the same as 
Humulin R, however, Lily's doc say the buffering agents reduce the 
likelyhood of clogs (crystalizing in the pump tubing).

I don't know whether or not the buffering agent has anything to do with 
lessening the 'sharp' effect of Humalog, I just know that the 5/1 
Humalog/Velosulin mix works better every day for Lily.

Bob Burnett sent me a post on some weird side effects he experienced with 
Humalog and the old 'alarm' went off -- Lily had complained several times 
of feeling funny or dizzy after bolusing in the morning for a high then 
stepping into the shower 10 minutes later and feeling downright low.
Testing did not confirm this but she still felt bad.
This has gone away. :-)

He also reported what appeared to be rebounds during the night from lows 
he could never confirm or catch.  Lily had the same problem, this is why 
we switched to the mix. This also has gone away. :-)

> this forum.  I'm sure my CDE knows nothing about it anyway and just
> tried to maintain an "air" of professionalism by giving me an answer
> instead of "gee, i'm not sure, I'll try to find out".  It's funny,
> sometimes I will give the CDE some new information or talk about some
> higher level issues than most patients talk about and the CDE seems to
> want to impress my Endo by telling him that she told me what I told
> her.. (er, does that make sense).. 
Aren't people funny??

Go to the drug store and order the Velosulin, you don't need a 
prescription, it is classified as 'regular' insulin.

>I could care less if she's trying to
> score Brownie points with my Doc.. i just think it's funny..  I don't
> think they expect patients to know much.. I figure I'm the captain of my
> ship and I need to know which way the way the wind's blowing at all
> times, and how to steer around those icebergs... which reminds me.. I'm
> going to go see Titanic tonight :)
> Forrest
> Michael wrote:
> > 
> > > Guys, I just met with my CDE today.. I go on the pump next Thursday by
> > >blah blah
> > > She also told me that it was unwise to mix the insulins.. She said why
> > > set yourself up for that kind of unpredictability.
> > 
> > The CDE at Lily's doc's office said exactly the opposite. Frankly,
> > they probably are just expressing their personal bias without
> > anything concrete to back it up.
> > 
> > If you look at the insert in the HUMALOG box (or the Lilly website)
> > you will see that there is a lengthy dissertation on mixing HUMALOG
> > with other insulins, the test results, etc....  Lilly expects this to
> > be done and has provided guidance and testing information in the
> > package.  However, nothing is mentioned about REGULAR insulin.
> > This is probably unimportant since the target audience for the
> > information was/is people who inject insulin and would normally use
> > type 'N' and ultra insulins along with either Humalog or Regular.
> > They certainly wouldn't use R and H together, it would not make
> > sense.  That just leaves the pumpers as the OddBalls. heh...
> > heh...:-)).
> > 
> > My daughter Lily continues on her 3rd 4-day stint with
> > the 5/1 Humalog/Velosulin mix (this is day 4). Her bg's have remained
> > more stable than before - particularly at night where she could be
> > very high or very low at 3:00 am. Night-time numbers have about 1/2
> > the swing they had on straight Humalog.
> > 
> > As I said before, the comments from Lily's doc office are favorable
> > about the mix and the ratio.  They did not seem to think an increase
> > in the Velosulin portion was a good idea because of the increased
> > absorbtion time it creates. (Didn't like a proposed 3/1 or more mix).
> > I don't think they have any solid info for this since there are only
> > 2 other patients in the practice that 'mix'.
> > 
> > Michael
> > email @ redacted