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[IP] FW: World First Living Donor Transplant of Islet Cells a Success



>> > World-First Living Donor Transplant of Islet Cells a Success
>> > Libraries
>> > Medical News		Keywords
>> > DIABETES, EDMONTON PROTOCOL, ISLET CELLS
>> > Contact Information
>> > Available for logged-in reporters only
>> > Description
>> > A University of Alberta surgeon, well known for his pioneering work in
>> > developing the Edmonton Protocol treatment for diabetes, has taken 
>>another
>> > important step in the fight against diabetes.
>> > Newswise - A University of Alberta and Capital Health surgeon, well 
>>known
>> > for his pioneering work in developing the Edmonton Protocol treatment 
>>for
>> > diabetes, has taken another important step in the fight against 
>>diabetes.
>> > On January 19, at Kyoto University Hospital, Dr. Koichi Tanaka and Dr.
>> > James Shapiro, along with a team of Japanese surgeons, removed part of 
>>a
>> > 56-year-old woman's pancreas. Dr. Shinichi Masumoto then isolated the
>> > living islets in the Kyoto Centre for Cell and Molecular Therapy. Under
>> > Dr. Shapiro's supervision, the team then transplanted the
>> > insulin-producing cells into the woman's 27-year-old diabetic daughter.
>> > The transplanted islets began producing insulin within minutes, 
>>explains
>> > Dr. Shapiro. "The reason I'm so excited about this is because normally 
>>the
>> > Edmonton Protocol is done with islets from brain-dead organ donors. 
>>Those
>> > islets are often severely injured from cold storage, transport time and
>> > the pancreas is severely damaged by toxins which circulate in the blood
>> > stream after brain death."
>> > "Our expectation is that these islets from near-perfect organs will 
>>work
>> > better, although it's too early to tell," he says.
>> > The recipients use the same drugs to prevent organ rejection as are 
>>used
>> > in the Edmonton Protocol.
>> > Dr. Shapiro was invited to participate in the operation in Kyoto, 
>>Japan,
>> > where he originally did living donor liver transplant training with Dr.
>> > Tanaka. Dr. Masumoto was previously based in Seattle and had been 
>>involved
>> > in Dr. Shapiro's international trial of the Edmonton Protocol before
>> > returning to Japan. Dr. Shapiro first suggested the idea of starting a
>> > living donor islet transplant program in Kyoto while lecturing there 
>>three
>> > years ago. Cadaveric organ donors are scarce in Japan, and living 
>>donation
>> > has very established roots in liver and kidney transplantation there.
>> > "Living donor islet transplants could allow many more desperate 
>>patients
>> > with type 1 diabetes to get successful islet transplants," says Dr.
>> > Shapiro. "The donor operation is relatively safe, but is not entirely
>> > devoid of serious potential risk," he added.
>> > A shortage of donor islet cells is the biggest obstacle preventing
>> > implementation for all patients who need it, Shapiro added.
>> > The mother of the diabetic daughter was in perfect health, while her
>> > daughter has been on the cadaver donors transplant list since September
>> > 2004. Before the surgery, the woman had been subject to severe low 
>>blood
>> > sugar coma attacks, and her glucose control has been transformed by the
>> > transplant.
>> > Website: http://www.med.ualberta.ca/islet
>> > <http://www.med.ualberta.ca/islet>
>> > Photos available upon request
>> >
>> >
>> > Denise Owens
>> > Paralegal
>> > Perkins Coie LLP
>> > 101 Jefferson Drive
>> > Menlo Park,  CA  94025-1114
>> > Phone (650) 838-4384
>> > Fax (650) 838-4350
>> > email @ redacted
>> >
>> >
>> >
>>
>>NOTICE: This communication may contain privileged or other confidential 
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>>reply email and immediately delete the message and any attachments without 
>>copying or disclosing the contents. Thank you.
.
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