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[IP] Tungstate Improves Glucose Homeostasis in Diabetic Rats
WESTPORT, CT (Reuters Health) Feb 13 - Administration of sodium tungstate
markedly reduces glycemia in a rat model of type 2 diabetes, Spanish
researchers report in the January issue of Diabetes.
Dr. Joan J. Guinovart from Universitat de Barcelona and colleagues have
previously shown that tungstate lowers blood glucose levels in rats made
insulin deficient to simulate type 1 diabetes. In the current study, the
researchers administered tungstate orally to 7.5-week-old Zucker diabetic
fatty rats, which are "considered the closest available rat model to human
type 2 diabetes associated with obesity."
The animals had begun to show hyperglycemia, and the treatment temporarily
reversed this for about 10 days. Glucose levels then rose again but stabilized
at about 200 mg/dL at day 24. In contrast, the glucose level of untreated rats
rose to a maximum value of 450 mg/dL.
Tungstate treatment caused serum triglyceride levels to fall by 42%, and
normalized hepatic concentrations of glucose-6-phosphate. The researchers also
found that the treatment led to 55% higher glycogen levels in the liver
compared with untreated diabetic or healthy rats. Treatment did not cause a
significant change in phosphotyrosine-modified proteins in cultured
hepatocytes from diabetic animals.
"These data suggest that tungstate administration to Zucker
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