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[IP] FW: Diabetes In Control Newsletter Issue 37 January 30, 2001
From: Diabetes In Control Newsletter
[mailto:email @ redacted]
Sent: Wed, January 31, 2001 1:52 AM
Glucose Monitoring in the 21st Century
Flowing Interstitial Fluid as a Medium for
Painless Continuously Monitoring Glucose
Learn about a glucose monitor that measures the concentration of glucose
in a steady stream of interstitial fluid (ISF) that is collected in a
patch outside the body. www.diabetesincontrol.com/feature22.htm
This newsletter is the condensed version. If you would like to see the
full newsletter got to www.diabetesincontrol.com/issue37
ITEMS For The Week:
Diabetes Increases Risk of All-Cause and CHD Mortality in US Men
Diabetes among men is a strong risk factor for all-cause mortality and
death from coronary heart disease, and men with both CHD and diabetes are
at particularly high risk, according to data from the US Physicians'
In the study population, "diabetes more than doubled the risk of all-cause
mortality and tripled the risk of death from heart disease. Men who have a
combination of diabetes and prior heart disease have nearly 5 times the
risk of death from all causes and 12 times the risk of death from heart
disease. For more details www.diabetesincontrol.com/issue37/item1.htm
More Evidence Linking Smoking to Diabetes
Cigarette smoking is now further implicated as a culprit of impaired
glucose tolerance. According to findings published recently in the Annals
of Internal Medicine, risk of impaired fasting glucose and type 2 diabetes
increases in a dose-dependent manner with the number of cigarettes smoked
per day and the number of pack-years of exposure. Nakanishi et al perceive
the findings as evidence that smoking is a "modifiable risk factor that
can be targeted" for diabetes prevention.
The cohort consisted of 1,266 Japanese businessmen, 35 to 59 years of age,
who underwent complete physical examinations annually for five years.
Unlike some previous studies, this one used the newest 1997 American
Diabetes Association and 1998 World Health Organization criteria for
impaired fasting glucose (>/=110 mg/dL but <126 mg/dL) and for type 2
diabetes (fasting plasma glucose >/=126 mg/dL or receipt of hypoglycemic
medications). During follow-up, 87 subjects developed impaired fasting
glucose and 54 developed type 2 diabetes, according to these criteria. For
Aspirin Therapy Underutilized by People With Diabetes
A product that costs less then 3 cents a day, that can prevent heart
attacks is under used, why?
A recently completed study conducted by the CDC found aspirin therapy,
known to help prevent heart attacks, was not regularly used by adults with
diabetes who already had cardiovascular disease (CVD), and was taken even
less by those with risk factors for heart disease. We need to get the
word out on this.
Sometimes we assume that the doctor told the patient about the benefits of
taking a small dose of aspirin daily. Maybe the patient forgot why he or
she was taking it and just stopped. If we want the patient to be
compliant, we need to keep reinforcing them with positive reasons and
education if we expect them to continue on a therapy that is meant to
prevent something, rather then treat something.
Diabetes Rates Rise Another 6 Percent in 1999-No End In Sight
Diabetes rates rose a striking 6 percent among adults in 1999
according to researchers at the Centers for Disease Control and Prevention
(CDC). The new findings are reported in the February issue of Diabetes
Care, a journal of the American Diabetes Association, and are further
evidence that diabetes is a major public health threat of epidemic
proportions. Currently more than 16 million Americans have diabetes and
about a third do not know they have the disease.
This new report is a follow-up to a study CDC released in September
showing that from 1990 to 1998 diagnosed diabetes, including gestational
diabetes, rose 33 percent (4.9 percent to 6.5 percent) among U.S. adults.
That study also linked the increase in diabetes with the rising rates of
obesity, a major risk factor for diabetes. The prevalence of obesity
increased significantly from 17.9 percent in 1998 to 18.9 percent in 1999,
an increase of 5.6 percent in one year and 57 percent from 1991. For
complete results: www.diabetesincontrol.com/issue37/item5.htm
Experts downplay heart benefits of wine
A panel of physicians urged doctors to downplay the potential
heart-healthy effects of red wine and encourage patients to exercise and
eat more fruits and vegetables.
The appealing idea that red wine can protect against heart disease has
gained currency thanks to studies showing a lower rate of heart disease
among people who regularly drank moderate amounts of wine.
But it remains unclear whether components in wine or the heart-healthy
lifestyles of wine lovers are behind this boost in cardiac protection, say
researchers writing in the January 23 issue of Circulation, a journal of
the American Heart Association (AHA).
Wine drinkers, for example, tend to be thinner, to exercise more and to
drink with meals, all of which may help remove artery-clogging fats from
their bloodstreams, they explain.
For the details: www.diabetesincontrol.com/issue37/item7.htm
Interstitial glucose concentration and glycemia: implications for
continuous subcutaneous glucose monitoring
Department of Diabetology, Institut National de la Santi et de la
Recherche Midicale Paris, France; National Applied Science, Portland,
Oregon 97224; and Department of Chemistry, University of Kansas, Lawrence,
The changes in plasma glucose concentration and in interstitial glucose
concentration, determined with a miniaturized subcutaneous glucose sensor,
were investigated in anesthetized.
First, after a glucose load, the magnitude of the increase in interstitial
glucose, estimated through a one-point calibration procedure, was 70% of
that in plasma glucose. We propose that this is due to the effect of
endogenous insulin on peripheral glucose uptake.
Second, during the spontaneous secondary decrease in plasma glucose after
the glucose load, interstitial glucose decreased faster than plasma
glucose, which may also be due to the effect of insulin on peripheral
Third, during insulin-induced hypoglycemia, the decrease in interstitial
glucose was less marked than that of plasma glucose, suggesting that
hypoglycemia suppressed transfer of glucose into the interstitial tissue;
subsequently, interstitial glucose remained lower than plasma glucose
during its return to basal value, suggesting that the stimulatory effect
of insulin on peripheral glucose uptake was protracted.
If these observations obtained in rats are relevant to human physiology,
such discrepancies between plasma and interstitial glucose concentration
may have major implications for the use of a subcutaneous glucose sensor
in continuous blood glucose monitoring in diabetic patients.
Death By Chocolate
High blood glucose levels are putting half of adults at higher risk of
fatal heart attacks, says a UK study
Half of adults have increased risk of fatal heart attacks and strokes
because of raised blood glucose levels, according to a UK study. But the
vast majority of these people would not be classed as diabetic. They
might be in the Twilight Zone.
(The Twilight Zone- See feature www.diabetesincontrol.com/feature19.htm )
Kay-Tee Khaw and her team at Cambridge University identified 4,662 men
aged 45 to 79 who had had their blood glucose concentration measured in
1995 as part of the European Prospective Investigation of Cancer and
Nutrition in Norfolk.
They found that risk of death from all causes, but from heart disease in
particular, increased with increasing blood glucose concentrations. Some
82 per cent of the deaths were associated with increased blood glucose,
but at levels below those required for a diagnosis of diabetes.
Even mildly elevated blood glucose seems to predict cardiovascular
disease. For more on this story:
Alteon's ALT-946 Demonstrates Protective Effect on Kidney
Alteon Inc. announced today that a study of ALT-946, a novel Advanced
Glycosylation End-product (A.G.E.) Formation Inhibitor, is published in
the current issue of the medical journal Diabetologia [Diabetologia (2001)
44:108-114]. ALT-946 is a pre-clinical lead candidate in a novel class of
A.G.E. Formation Inhibitor compounds developed by Alteon.
Renoprotective effects of a novel inhibitor of advanced glycation" was
authored by a research team led by Mark E. Cooper, M.D., Ph.D., Professor,
Department of Medicine and Endocrine Unit, University of Melbourne,
Australia, as well as researchers from Alteon. The study compared ALT-946
to Pimagedine, Alteon's clinical lead A.G.E. Formation Inhibitor, in rats
with experimental diabetic nephropathy. A.G.E.s and A.G.E. crosslinks have
been shown to play an important role in the development of diabetic
complications. To find out more:
Free Cookbook Celebrity Chefs Across America-The Ingredients For
Celebrity Chefs Across America The Ingredients for Managing Diabetes, a
new cookbook consisting of more than 50 recipes, a variety of
informational resources and suggested meal plans to help people manage
Written by Anthony Dias Blue, Celebrity Chefs Across America celebrates
our nations regional cuisines with recipes shared by 15 great chefs from
communities in every corner of the map. Sponsored by SmithKline Beecham
To obtain your free copy, just call 1-800-282-6352 and request a free copy.
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