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RE: [IP] This from Diabetes in Control



> > their claim of
>  islet cell transplant being a 'cure' for T1 diabetes. This is such a
> misleading
>  statement A trx. only
> takes care of some of the symptoms of diabetes, but until they find a
> cure for the body's autoimmune system actually attacking the islets to
> begin with, they will not have a true 'cure'!!!
> 
>  Sylvia,
> Could you clarify please? Are you saying islet transplant would not be a
> cure because the body's autoimmune system might attack the islets again?
> Also, what's 'trx?' A transplant?
> 

Perhaps this will put it in perspective:

<quote NDIC clearinghouse>
Researchers are trying to find new approaches that will allow 
successful transplantation without the use of immunosuppressive drugs, 
thus eliminating the side effects that may accompany their long-term 
use.

Rejection is the biggest problem with any transplant. The immune system 
is programmed to destroy bacteria, viruses, and tissue it recognizes as 
"foreign," including transplanted islets. Immunosuppressive drugs are 
needed to keep the transplanted islets functioning.

Immunosuppressive Drugs

The Edmonton protocol uses a combination of immunosuppressive drugs, 
also called antirejection drugs, including dacliximab (Zenapax), 
sirolimus (Rapamune), and tacrolimus (Prograf). Dacliximab is given 
intravenously right after the transplant and then discontinued. 
Sirolimus and tacrolimus, the two main drugs that keep the immune 
system from destroying the transplanted islets, must be taken for life.

These drugs have significant side effects and their long-term effects 
are still not known. Immediate side effects of immunosuppressive drugs 
may include mouth sores and gastrointestinal problems, such as stomach 
upset or diarrhea. Patients may also have increased blood cholesterol 
levels, decreased white blood cell counts, decreased kidney function, 
and increased susceptibility to bacterial and viral infections. Taking 
immunosuppressive drugs increases the risk of tumors and cancer as 
well.

Researchers do not fully know what long-term effects this procedure may 
have. Also, although the early results of the Edmonton protocol are 
very encouraging, more research is needed to answer questions about how 
long the islets will survive and how often the transplantation 
procedure will be successful.
</quote>
.
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