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[IP] Check this out!



A friend sent me this:  check it out!  Anyone know anything about it?

> Thursday December 7 5:22 PM ET
> 
> Animal Study Shows Gene Therapy May Help Diabetics
> 
> NEW YORK (Reuters Health) - Early research results in mice suggest it may be
> possible to treat diabetes with gene therapy, possibly ridding patients of
> the need to take daily injections of insulin to control their disease.
> 
> A team of Canadian and US scientists was able to genetically engineer gut
> cells known as K cells to produce human insulin in mice. This success means
> that researchers could theoretically use gene therapy to overcome the
> fundamental dysfunction behind diabetes in humans, according to a report in
> the December 8th issue of Science.
> 
> Diabetes is a chronic disease in which the body either does not produce or
> does not properly use insulin, a hormone that helps control blood sugar, or
> glucose. Normally, pancreas cells called beta cells release insulin in
> response to food intake, moving glucose from the blood to body cells to be
> used for energy.
> 
> With type 1 diabetes, however, the immune system attacks beta cells, leaving
> these diabetics with no insulin-producing cells. They must inject synthetic
> insulin every day. People with type 2 diabetes, the form linked to obesity,
> are unable to properly use insulin. Many of these diabetes patients have to
> inject insulin or take it in pill form.
> 
> In the current study, researchers looked at whether they could use genes to
> bestow insulin-producing powers upon K cells, which are situated in the
> stomach and small intestine.
> 
> A team led by Timothy J. Kieffer of the University of Alberta in Edmonton,
> Canada, introduced a human insulin gene into K cells and then engineered
> mice to carry the new K cells. The investigators found the mice were able to
> produce human insulin. Moreover, the engineered K cells protected the
> animals from developing diabetes even after their insulin-producing beta
> cells were destroyed.
> 
> Kieffer told Reuters Health that K cells are ``excellent candidates'' for
> beta cell substitutes in diabetics because K cells already have the
> ``necessary machinery'' to store and release insulin.
> 
> K cells naturally secrete a hormone called GIP immediately after a meal,
> Kieffer explained. ``Our rationale,'' he said, ``was that if we could
> engineer these K cells to produce insulin, it should be made and stored in
> the cells in advance, ready to be released promptly in response to a meal.''
> 
> Kieffer stressed that these findings in mice only show that the concept of
> gene therapy for diabetes is feasible. He said the remaining obstacles
> include figuring out how to get insulin genes into human K cells.
> 
> SOURCE: Science 2000;290:1959-1962.
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From: "Jon Goff" <email @ redacted>
To: <email @ redacted>
Subject: Diabetes Research
Date: Fri, 8 Dec 2000 06:43:46 -0500
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Thursday December 7 5:22 PM ET

Animal Study Shows Gene Therapy May Help Diabetics

NEW YORK (Reuters Health) - Early research results in mice suggest it may be
possible to treat diabetes with gene therapy, possibly ridding patients of
the need to take daily injections of insulin to control their disease.

A team of Canadian and US scientists was able to genetically engineer gut
cells known as K cells to produce human insulin in mice. This success means
that researchers could theoretically use gene therapy to overcome the
fundamental dysfunction behind diabetes in humans, according to a report in
the December 8th issue of Science.

Diabetes is a chronic disease in which the body either does not produce or
does not properly use insulin, a hormone that helps control blood sugar, or
glucose. Normally, pancreas cells called beta cells release insulin in
response to food intake, moving glucose from the blood to body cells to be
used for energy.

With type 1 diabetes, however, the immune system attacks beta cells, leaving
these diabetics with no insulin-producing cells. They must inject synthetic
insulin every day. People with type 2 diabetes, the form linked to obesity,
are unable to properly use insulin. Many of these diabetes patients have to
inject insulin or take it in pill form.

In the current study, researchers looked at whether they could use genes to
bestow insulin-producing powers upon K cells, which are situated in the
stomach and small intestine.

A team led by Timothy J. Kieffer of the University of Alberta in Edmonton,
Canada, introduced a human insulin gene into K cells and then engineered
mice to carry the new K cells. The investigators found the mice were able to
produce human insulin. Moreover, the engineered K cells protected the
animals from developing diabetes even after their insulin-producing beta
cells were destroyed.

Kieffer told Reuters Health that K cells are ``excellent candidates'' for
beta cell substitutes in diabetics because K cells already have the
``necessary machinery'' to store and release insulin.

K cells naturally secrete a hormone called GIP immediately after a meal,
Kieffer explained. ``Our rationale,'' he said, ``was that if we could
engineer these K cells to produce insulin, it should be made and stored in
the cells in advance, ready to be released promptly in response to a meal.''

Kieffer stressed that these findings in mice only show that the concept of
gene therapy for diabetes is feasible. He said the remaining obstacles
include figuring out how to get insulin genes into human K cells.

SOURCE: Science 2000;290:1959-1962.
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