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[IP] Insulin desensitization with lispro and an insulin pump in a 5 year old child

 Ann Allergy Asthma Immunol 2000 Nov;85(5):395-7

Insulin desensitization with insulin lispro and an insulin pump in a 
5-year-old child.

Eapen SS, Connor EL, Gern JE

Department of Medicine, University of Wisconsin-Madison, USA.

[Medline record in process]

BACKGROUND AND OBJECTIVE: Allergic reactions to insulin, though rare, can 
have serious consequences in children with type I diabetes mellitus. We 
report a case of insulin allergy in a 5-year-old child in whom insulin 
desensitization was accomplished using an insulin pump. METHODS AND RESULTS: 
A 5-year-old girl with insulin-dependent diabetes mellitus (IDDM) developed 
progressive reactions to insulin and was found to have positive intradermal 
skin tests to regular and NPH insulin. Addition of oral antihistamine and 
co-administration of subcutaneous dexamethasone along with the insulin failed 
to control her symptoms. The patient was therefore hospitalized and 
desensitized to insulin using an insulin pump and insulin lispro. CONCLUSION: 
An insulin pump can be used for insulin desensitization in selected children. 
The slow constant infusion rate provided by the pump may be an ideal means of 
achieving insulin desensitization. In addition, insulin lispro, a synthetic 
insulin analog, should be considered for use in insulin-allergic individuals.

PMID: 11101184, UI: 20550885    
 <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11101184&dopt=Abstract">Entrez-PubMed</A> 
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