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Re: [IP] Re: Islet cells



Here's a link to Harvard's site with the t-cell research:

http://www.mgh.harvard.edu/depts/diabetes/type1research.htm
--- Becky <email @ redacted> wrote:
> i heard a program on NPR's talk of the nation science friday last summer that
> addressed research
> for a potential cure. they were doing it at some university in massachusetts,
> (might have been
> harvard but i'm not sure) where they were trying to suppress the autoimmune
> reaction in type-1
> diabetic mice with some drug that apparently is already in use for something
> else. when they got
> the autoimmune reaction to stop, they were shocked to find that the diabetes
> resolved itself in
> the mice spontaneously. apparently what happened was that latent stem cells
> floating around in the
> mice's bodies spontaneously regenerated islet cells and started producing
> insulin. what i want to
> know is will they ever need any human guinea pigs? because if they do i am
> THERE, man =)
> 
>  i got a transcript of the program but i am not sure where it is now, but if
> anyone wants to look
> into it it was "talk of the nation science friday" broadcast on july 24,
> 2001. if you find any
> more info on that study let me know.
> 
> becky =) (dx'd 1/24/92 at age 10, pumping since 11/21/01)
> 
> > I need to comment about this article from The Globe.  It talks about
> > the beta cells, or islet cells and how to 'grow' new ones or figure
> > out how they turn on and off....something like that.  Anyway, is
> > that really the key to diabetes?  I mean, my understanding is that
> > this is an auto-immune system where the body's own immune system has
> > arbitrarily decided to attack its own islett cells thus shutting
> > them down and thus the need for external resources of insulin. 
> > Well, wouldn't the key factor for this be then to figure out WHY the
> > body chose the islett cells to attack, and how to stop the immune
> > system from attacking its own body parts.
> 
> They're working on that too. There's a vaccine trial ... I think in 
> Israel ... that addresses this issue. As I understand it, a type one 
> that has been diabetic for many years stops making the antibodies 
> after a while and so is eligible for vaccine therapy IF there were a 
> way to restore islet function. The big question for me is whether 
> this can be accomplished without immune suppression drugs. When they 
> achieve three things, there will be a true cure.
> 1) regenerate islets
> 2) do 1 with tissue the body will accept completely
> 3) suppress the body's urge to kill the islet cells by turning OFF 
> the appropriate T cell response.
> 
> Michael
> 
> >  It would not matter whose
> > cells were in your body (ie; cell transplant or cloned cells) if the
> > autoimmune system is whacked out then those cells are not any safer
> > than the ones you were born with, right????  Or am I missing
> > something.  I think the key is figuring out the immune system and
> > how to stop it from attacking ANY cells!!!!
> 
> 
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