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RE: [IP] Re (IP) Type 1 and 2--antibodies



what happens if you aren't positive, but are still type one, like in about 
20 percent according to your statistics.  --Gianna


>From: "Susan Schilling" <email @ redacted>
>Reply-To: email @ redacted
>To: <email @ redacted>
>Subject: RE: [IP] Re (IP) Type 1 and 2--antibodies
>Date: Mon, 16 Aug 1999 09:40:42 -0700
>
>I work for a reference laboratory that routinely performs autoantibody
>testing for many autoimmune diseases such as IDDM.  Hope this clears up any
>confusion for those of you interested.  Any specific questions may be
>directed to me personally at email @ redacted
>
>Approximately 15% of all diabetic patients exhibit insulin-dependent
>diabetes mellitus (IDDM), also known as Type I diabetes.  IDDM reflect the
>autoimmue destruction of insulin-producing beta cells of the islets of
>Langerhans in the pancreas.  Although an immunofluorescent assay to detect
>islet cell autoantibodies is highly snesitive for predicting and diagnosing
>IDDM, its widespread utility is limited by poor precision and the need for
>human pancreatic tissue.
>
>Clinical studies have shown that most islet cell autoantibodies are 
>directed
>aganinst one of two major islet cell antigens, glutamic acid decarboxylase
>(GAD) and the tyrosine phosphatase termed islet antigen-2 (IA-2).  GAD
>antibodies are found in 70-80% of newly diagnosed IDDM patients, but are
>also found occasionally in other organ specific autoimmune diseases.
>Approximately 10% of first degreee relatives of IDDM patients exhibit GAD
>antibodies, and 50% of these seropositive relatives will develop IDDM 
>within
>5 years.
>
>IA-2 antibodies are found in 60-70% of newly diagnosed IDDM patients, and
>are more specific for IDDM than GAD antibodies.  Approximately 5% of first
>degree relatives of IDDM patients exhibit IA-2 antibodies, and 80% of these
>seropositive relatives will develop IDDM within 5 years.
>
>Investigations of the relationship between GAD antibody detection and IA-2
>antibody detection is sera from IDDM patients revealed only partial 
>overlap;
>that is, some sera contained GAD antibody only, some sera contained IA-2
>antibody only, and some sera contained both antibodies.  More importantly, 
>a
>positive result for at least one of these autoantibodies was found in over
>90% of IDDM patients.
>
>Thus, a combination of GAD antibody and IA-2 antibody testing provides
>greater sensitivity for IDDM detection than measurement of either of these
>autoantibodies alone.  Additional studies have shown that the sensitivity 
>of
>this combination testing approach is comparable to or better that the
>sensitivity of the islet cell autoantibody assay.
>
>GAD antibodies and IA-2 antibodies are measured using radioimmunoassays
>(RIA).
>
>Susan S.
>IDDM 16 years\MM pump 2 weeks
>
>-----Original Message-----
>From: email @ redacted [mailto:email @ redacted]On Behalf
>Of Ted Quick
>Sent: August 15, 1999 5:30 AM
>To: email @ redacted
>Subject: Re: [IP] Re (IP) Type 1 and 2--antibodies
>
>
>gianna marzilli wrote:
> >
> > is there a difference between  islet and autoimmune antibodies? -Gianna
>
>Perhaps. Thing is that autoimmune antibodies may refer to more than islet
>antibodies, since the autoimmune system can destry other things besides
>Beta (islet) cells. Of course around here that's a little less likely than
>elsewhere, seeing what our main subject is....
>
>Ted Quick
>email @ redacted
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