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Re: [IP] RE (IP) MM vs D
This business of the timing of basal delivery boluses is not relevant to
the difference in pumps. Whether a pump delivers a drop of basal insulin
every 5 or 15 min would have no measurable effect on blood insulin. That's
because , as Michael notes, it is going under the skin, not into the blood.
By the time this train of insulin drops gets absorbed 2 hours later it will
look like a fairly steady rate in the blood no matter what. There are a
host of other more relevant factors that affect the rate of absorption of
insulin from under the skin, and these are quite variable, not only from
site to site, but also with amount of insulin, skin temperature, body
hydration, tissue pressure, etc, etc. If one just monitored blood insulin
levels (which is all that really matters), it would not be possible to tell
whether the insulin came from a MM or D pump.
> Physiological studies show that the pancreas delivers basal insulin
> approximately every three minutes.
Bear in mind that the pancreas delivers the insulin directly to the
blood stream wheras a pump delivers it to subcutaneous tissue where
it must infuse into the blood stream. Even with the fastest insulin
(Humalog) this process take almost 2 hours and the initial effects
are only seen after 15 to 30 minutes so the rate of delivery from the
pump really make no difference at all.
>(Wayne, John...do your sources
> state differently?) The issue for most people, however is the degree
> of control they have with whatever delivery time from the pump they
> choose to use to meet their own personal physiological differences.
> Choose the pump that meets your lifestyle, personal preferences, and
> comfort level. They both work well.
> Barbara B.
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