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RE: [IP] Autoimmune Diseases Diabetes Type 1

Continuing levels of circulating antibodies are an indication of immune
reactivity to antigen presence.  One might ask, "What antigens are being
reacted to since my beta cells were already destroyed?"  Although no specific
trials have addressed this issue a recent trial done for other reasons in mice
(recent New England Journal of Medicine, about a month ago concerning
immunomodulation after transplant therapies) suggests that beta cells continue
to reproduce in number no matter the ongoing destruction of them by the
circulating antibodies.  It makes it appear that at least one reason that
clinical resolution of hyperglycemic symptoms does not occur is secondary to
ongoing destruction as the beta cells are reproduced.

Another reason to watch antibody levels is to assess for the risk of
progression to other autoimmune conditions classically related to autoimmune
diabetes mellitus (aka Type I DM).  Some of these conditions include
hypothyroidism, pernicious anemia, gastroparesis, and vitilligo.



From: email @ redacted on behalf of Felix Kasza (lists)
Sent: Sat 4/12/2008 8:58 AM
To: email @ redacted
Cc: email @ redacted
Subject: RE: [IP] Autoimmune Diseases Diabetes Type 1

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Hi Liz,

 > What would it mean if you're told that
 > you have a lot of antibodies years after
 > diagnosis?

I would guess somebody looked into sustained high antibody titres
and whether they are correlated with additional auto-immune
diseases -- but I cannot find anything on Pubmed, sorry. Meyer
Davidson says that antibody levels _may_ decrease (or may not,
obviously), but without any interpretation.

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