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[IP] Re: H1c test Question
Michael, is this the one you're referring to?
The source for the following info came from this site:
http://www.faqs.org/ (search for A1C)
...(Henrik) Mortensen's work shows that after a change
in average bG level, the HbA1c level restabilizes after
about 4 weeks. This has several consequences.
Clinically, the most important are these:
First, the HbA1c is an exponentially weighted average
of blood glucose levels from the preceding 4 weeks,
with the most recent 2 weeks being by far the most
Second, measuring HbA1c less often than monthly results
in unmonitored gaps between measurements. To use HbA1c
as a continuous monitoring tool, you need to check it
at least once a month.
Third, it is worthwhile checking the HbA1c of newly
diagnosed patients as often as once a week to determine
the effectiveness of the newly imposed treatment.
Reference 1: American Diabetes Association, Tests of
Glycemia in Diabetes, Diabetes Care 23:S80-S82, January
2000 Supplement 1.
Available on the web at
or check the home page at http://diabetes.org and
follow the link to
"Clinical Practice Recommendations".
Reference 2: Kilpatrick ES, Maylor PW, Keevil BG:
Biological Variation of Glycated Hemoglobin. Diabetes
Care 21:261-264, February 1998.
Available on the web at
Reference 3: Mortensen HB, Christophersen C:
Glucosylation of human haemoglobin a in red blood cells
studied in vitro. Kinetics of the formation and
dissociation of haemoglobin A1c. Clinica Chimica Acta
134:317-326, 15 November 1983.
Reference 4: Mortensen HB, Volund A, Christophersen C:
Glucosylation of human haemoglobin A. Dynamic variation
in HbA1c described by a biokinetic model. Clinica
Chimica Acta 136:75-81, 16 January 1984.
Reference 5: Mortensen HB, Volund A: Application of a
biokinetic model for prediction and assessment of
glycated haemoglobins in diabetic patients.
Scandinavian Journal of Clinical and Laboratory
Investigation 48:595-602, October 1988.
Take care, Kerri
~*~this is where my quote would be if I had one~*~
Actually they done some research that seems to show
that when the doc does the A1c's on a regular basis,
the patients tend to have lower values. The
anticipation of having your performance reviewed
creates a stimulus for better control. Really, honest,
etc.... there is a paper on it somewhere buried in the
bowels of Medline.
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