[Previous Months][Date Index][Thread Index][Join - Register][Login]
[Message Prev][Message Next][Thread Prev][Thread Next]

[IP] lispro and heparin

 <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11689276&dopt=Abstract">Entrez-PubMed</A> 
 Diabetes Res Clin Pract 2001 Dec;54(3):209-12  
A patient with subcutaneous-insulin resistance treated by insulin lispro plus 

Tokuyama Y, Nozaki O, Kanatsuka A.

Diabetes Center, Kasori Hospital, 1835-1, Kasori, Wakaba-ku, Chiba 264-9100, 
Japan. email @ redacted

Severe resistance to subcutaneous insulin but sensitivity to intravenous 
insulin persisted for 11 years in a 23-year-old diabetic woman. Several 
therapeutic trials revealed that (1) intravenous regular insulin improved her 
metabolic control; (2) continuous subcutaneous infusion (CSII) treatment with 
regular insulin or insulin lispro caused hyperglycemic period with 
hypoinsulinemia and hypoglycemic period with hyperinsulinemia alternately; 
(3) adding heparin to insulin lispro in CSII resulted in dramatic increase of 
serum insulin level and improvement of glycemic control; and (4) regular 
insulin plus heparin in CSII could not increase serum insulin level and thus 
the glycemic values was not improved. From these results, the patient 
followed the insulin lispro plus heparin protocol and obtained a better 
glycemic control without any adverse events. Effectiveness of this therapy 
may lead us to further understanding of pathophysiology of this syndrome.

PMID: 11689276 [PubMed - indexed for MEDLINE]   
for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
send a DONATION http://www.Insulin-Pumpers.org/donate.shtml