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RE: [IP] Mixing H&R


Here is Bill VanAntwerp's original message to Buddy, where he cited the
specifics on the buffering (yeah, I know I'm a pack rat ;-)) Sorry if the
formatting is a bit screwy ...

original message:

"From: 	buddybarber
Reply To: 	email @ redacted
Sent: 	Friday, January 16, 1998 8:53 AM
To: 	email @ redacted
Subject: 	Re: [IP] Humalog - clarifying the infusion site problem

Could it be that the buffers help stabilize it for the length of time it is
also unrefrigerated? Makes sense to me. I like the speed at which the
Humalog acts but I dislike the fact that it "MIGHT" subtract from the length
of time I get from a set. I can cope with an occasional high by injecting a
bit of Humalog in the QR which works very well thanks, and still get 6 days
from a set. I always believed if it ain't broke don't fix it.

Feeling GREAT !

Buddy '-)"

Bill's reply:

"I will be writing my thoughts about Humalog to the group soon, but one
thing that is worth discussing now is the ideas of different buffers.Humalog
and Velosulin are BOTH buffered with phosphate and use the same preservative
system, i.e. m-cresol.  Both have the same temperature stability at least as
measured in any lab experiment that I know about. Any other ideas are really


Bob Burnett
mailto:email @ redacted


> > Any thoughts anyone, before I make a guinea-pig of myself?
> >
> You might want to pose the question privately to Bill at MiniMed. He
> has knowledge of the chemistry of the buffering solutions in the
> various insulins. He once stated in a post that Humalog and Velosulin
> used the same buffering agent (if I am quoting him correctly).
> Michael
> email @ redacted

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